SCHEMBL18292000

SCHEMBL18292000

CO/C=C(/C(=O)OC)c1ccccc1COc1nccnc1C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 4/20 0.38
LMNA P02545 1/20 0.35
KLKB1 P03952 1/20 0.35
OPRL1 P41146 1/20 0.35
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
SGMS2 Q8NHU3 1/20 0.34
CD38 P28907 1/20 0.34
HDAC6 Q9UBN7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30368058 1.00 HIF1A (0.38) HIF1ALMNAKLKB1OPRL1MAOA
SCHEMBL20817006 0.90 OPRL1 (0.35) HIF1AKLKB1OPRL1MAOAMAOB
SCHEMBL18291950 0.86 SGMS2 (0.42) HIF1ALMNAMAOAMAOBSGMS2
SCHEMBL30367824 0.86 SGMS2 (0.42) HIF1ALMNAMAOAMAOBSGMS2
SCHEMBL5688372 0.81 SGMS2 (0.40) LMNASGMS2
SCHEMBL29709962 0.81 SGMS2 (0.40) LMNASGMS2
SCHEMBL20823554 0.81 HCRTR1 (0.35) HIF1ASGMS2
SCHEMBL20822846 0.81 MAPK8 (0.47) LMNASGMS2
SCHEMBL29470271 0.81 HPGD (0.43)
Picoxystrobin SCHEMBL18977 0.80 HIF1A (0.39) HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230123440-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME SYNGENTA PARTICIPATIONS AG (CH) 2023-04-20 US disclosed
US-20210007353-A1 COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 US disclosed
US-20190082687-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME SYNGENTA PARTICIPATIONS AG (CH) 2019-03-21 US disclosed
WO-2016193267-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME SYNGENTA PARTICIPATIONS AG (CH) 2016-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230123440-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME DDT, MLEC, MSMO1 HIF1A 3683/4885LMNA 2239/4885KLKB1 2101/4885
US-20210007353-A1 COMPOUNDS AND COMPOSITIONS HAVING KNOCK-DOWN OR BLOOD FEED INHIBITION ACTIVITY AGAINST INSECT PESTS NIT2, KISS1R, NNMT HIF1A 4126/4885LMNA 1434/4885KLKB1 906/4885
US-20190082687-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME DDT, MLEC, MSMO1 HIF1A 3683/4885LMNA 2239/4885KLKB1 2101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.