Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438928 | 0.91 | — | — | |
| SCHEMBL11670009 | 0.83 | HPGD (0.57) | HPGDTP53HSD11B1ALDH1A1ATM | |
| SCHEMBL24363715 | 0.79 | HPGD (0.59) | HPGDTP53HSD11B1ALDH1A1GAA | |
| SCHEMBL1841803 | 0.79 | HPGD (0.48) | HPGDTP53HSD11B1ALDH1A1ATM | |
| SCHEMBL13749008 | 0.77 | HSD11B1 (0.47) | HPGDTP53HSD11B1ALDH1A1ATM | |
| SCHEMBL8395158 | 0.77 | HPGD (0.47) | HPGDTP53HSD11B1ALDH1A1ATM | |
| SCHEMBL11460238 | 0.76 | HPGD (0.50) | HPGDTP53HSD11B1ALDH1A1ATM | |
| SCHEMBL11466260 | 0.76 | HPGD (0.50) | HPGDTP53HSD11B1ALDH1A1ATM | |
| SCHEMBL9159626 | 0.76 | HPGD (0.50) | HPGDTP53HSD11B1ALDH1A1KMT2A | |
| SCHEMBL11652994 | 0.76 | HPGD (0.50) | HPGDTP53HSD11B1ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944292-B9 | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents | RENSSELAER POLYTECH INST (US) | 2016-07-06 | — | — | EP | claimed |
| EP-1944292-B1 | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents | RENSSELAER POLYTECH INST (US) | 2016-02-17 | — | — | EP | claimed |
| EP-2318372-B9 | LARGE SUBSTITUENT, NON-PHENOLIC AMINE OPIOIDS | RENSSELAER POLYTECH INST (US) | 2015-05-06 | — | — | EP | claimed |
| EP-2318372-B1 | LARGE SUBSTITUENT, NON-PHENOLIC AMINE OPIOIDS | RENSSELAER POLYTECH INST (US) | 2015-01-14 | — | — | EP | claimed |
| US-20140107143-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2014-04-17 | — | — | US | claimed |
| EP-1924559-B1 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECH INST (US) | 2014-04-16 | — | — | EP | claimed |
| US-8642615-B2 | Methods of using 8-carboxamido-2,6-methano-3-benzazocines | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2014-02-04 | — | — | US | claimed |
| US-20120302591-A1 | METHODS OF USING 8-CARBOXAMIDO-2,6-METHANO-3-BENZAZOCINES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2012-11-29 | — | — | US | claimed |
| US-8252929-B2 | 8-carboxamido-2,6-methano-3-benzazocines | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2012-08-28 | — | — | US | claimed |
| US-8026252-B2 | Large substituent, non-phenolic opioids and methods of use thereof | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2011-09-27 | — | — | US | claimed |
| WO-2009023567-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2009-02-19 | — | — | WO | claimed |
| EP-1944292-A1 | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2008-07-16 | — | — | EP | claimed |
| EP-1924559-A2 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2008-05-28 | — | — | EP | claimed |
| WO-2007014137-A2 | 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2007-02-01 | — | — | WO | claimed |
| US-20070021457-A1 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2007-01-25 | — | — | US | claimed |
| EP-1353909-B1 | 8-SUBSTITUTED-2,6-METHANO-3-BENZAZOCINES AND 3-SUBSTITUTED MORPHINANES AS OPIOIDRECEPTOR BINDING AGENTS | RENSSELAER POLYTECH INST (US) | 2005-04-06 | — | — | EP | claimed |
| EP-1359146-A2 | 8-substituted-2,6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents | Rensselaer Polytechnic Institute (US) | 2003-11-05 | — | — | EP | claimed |
| EP-1353909-A2 | 8-SUBSTITUTED-2,6-METHANO-3-BENZAZOCINES AND 3-SUBSTITUTED MORPHINANES AS OPIOIDRECEPTOR BINDING AGENTS | Rensselaer Polytechnic Institute (US) | 2003-10-22 | — | — | EP | claimed |
| US-20030187009-A1 | Analgesics, diarrhea, anticonvulsants, antitussive agents or drug abuse therapy | RENSSELAER POLYTECHNIC INSTITUTE | 2003-10-02 | — | — | US | claimed |
| WO-2002036573-A2 | 8- SUBSTITUTED-2, 6-METHANO-3-BENZAZOCINES AND 3-SUBSTITUTED MORPHINANES AS OPIOID RECEPTOR BINDING AGENTS | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2002-05-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021457-A1 | analgesics, antidiarrheal agents, anticonvulsants, antitussives, anti-addiction; 8-Substituted-2,6-methano-3-benzazocines | OPRM1, OPRK1, OPRL1 | HPGD 1037/4885TP53 4869/4885HSD11B1 2433/4885 |
| US-20140107143-A1 | QUATERNARY OPIOID CARBOXAMIDES | OPRK1, OPRM1, OPRD1 | HPGD 725/4885TP53 4883/4885HSD11B1 2302/4885 |
| US-20030187009-A1 | Analgesics, diarrhea, anticonvulsants, antitussive agents or drug abuse therapy | OPRM1, DDO, OPRK1 | HPGD 625/4885TP53 4884/4885HSD11B1 2073/4885 |
| US-20120302591-A1 | METHODS OF USING 8-CARBOXAMIDO-2,6-METHANO-3-BENZAZOCINES | HRH4, HRH3, HRH2 | HPGD 1196/4885TP53 4871/4885HSD11B1 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.