SCHEMBL18300366

SCHEMBL18300366

COCOc1ccc(C=CC(=O)O)cc1OCOC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.65
ALDH1A1 P00352 2/20 0.65
HPGD P15428 1/20 0.65
ALOX15 P16050 1/20 0.65
MAPK1 P28482 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
HSD17B10 Q99714 1/20 0.65
SNCA P37840 2/20 0.63
KMT2A Q03164 2/20 0.63
GAA P10253 1/20 0.63
POLB P06746 1/20 0.60
LMNA P02545 1/20 0.60
CA12 O43570 1/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
CA3 P07451 1/20 0.57
PKM P14618 1/20 0.57
CSNK2A2 P19784 1/20 0.57
CA4 P22748 1/20 0.57
CA6 P23280 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18300365 1.00 KDM4E (0.65) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL7290494 0.94 KDM4E (0.75) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL4679399 0.94 KDM4E (0.75) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL7290486 0.94 KDM4E (0.75) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL4679405 0.94 KDM4E (0.75) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL9329877 0.90 KDM4E (0.53) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL9329870 0.90 KDM4E (0.53) KDM4EALDH1A1HPGDALOX15MAPK1
SCHEMBL6034559 0.90 KDM4E (0.78) KDM4EALDH1A1HPGDLMNAAKR1C3
SCHEMBL6034563 0.90 KDM4E (0.78) KDM4EALDH1A1HPGDLMNAAKR1C3
SCHEMBL2743988 0.89 NFKB1 (0.56) KDM4EALDH1A1HPGDALOX15MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9611255-B2 Process for total synthesis of flavonoid compounds and isomers thereof COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-04-04 US claimed
US-20160362401-A1 PROCESS FOR TOTAL SYNTHESIS OF FLAVONOID COMPOUNDS AND ISOMERS THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-12-15 US claimed
US-20250248955-A1 PHENYL ACRYLIC ACID COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF LONGIVITRON (SUZHOU) BIOTECHNOLOGY CO., LTD (CN) 2025-08-07 US disclosed
EP-4512796-A1 PHENYL ACRYLIC ACID COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF Longivitron (Suzhou) Biotechnology Co., Ltd (CN) 2025-02-26 EP disclosed
WO-2023202559-A1 PHENYL ACRYLIC ACID COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF 朗捷睿(苏州)生物科技有限公司 2023-10-26 WO disclosed
US-9611255-B2 Process for total synthesis of flavonoid compounds and isomers thereof COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2017-04-04 US disclosed
US-20160362401-A1 PROCESS FOR TOTAL SYNTHESIS OF FLAVONOID COMPOUNDS AND ISOMERS THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-12-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160362401-A1 PROCESS FOR TOTAL SYNTHESIS OF FLAVONOID COMPOUNDS AND ISOMERS THEREOF UGT1A3, F3, UGGT1 KDM4E 3271/4885ALDH1A1 1408/4885HPGD 704/4885
US-20250248955-A1 PHENYL ACRYLIC ACID COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF APP, DDC, AGER KDM4E 1587/4885ALDH1A1 908/4885HPGD 994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.