Sugi Predict

Sugi Predict / Compounds / SCHEMBL18301511

SCHEMBL18301511

SCHEMBL18301511

C[C@@H](N/C=C/c1ccccc1)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 1/20 0.57
▸ NPC1 O15118 3/20 0.49
▸ RAB9A P51151 3/20 0.49
▸ TDP1 Q9NUW8 2/20 0.46
▸ GLA P06280 1/20 0.46
▸ CYP1A2 P05177 3/20 0.44
▸ HDAC1 Q13547 4/20 0.44
▸ HDAC2 Q92769 3/20 0.44
▸ HDAC6 Q9UBN7 3/20 0.44
▸ HDAC3 O15379 2/20 0.44
▸ HDAC4 P56524 2/20 0.44
▸ HDAC8 Q9BY41 2/20 0.44
▸ SMN1; SMN2 Q16637 4/20 0.44
▸ ALDH1A1 P00352 3/20 0.44
▸ MAPT P10636 2/20 0.44
▸ CYP2C9 P11712 2/20 0.44
▸ TNKS O95271 1/20 0.44
▸ HCAR2 Q8TDS4 1/20 0.44
▸ HDAC7 Q8WUI4 1/20 0.44
▸ HDAC10 Q969S8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL527788 1.00 HTT (0.57) HTTNPC1RAB9ATDP1GLA
SCHEMBL527789 1.00 HTT (0.57) HTTNPC1RAB9ATDP1GLA
SCHEMBL527790 1.00 HTT (0.57) HTTNPC1RAB9ATDP1GLA
SCHEMBL668826 1.00 HTT (0.57) HTTNPC1RAB9ATDP1GLA
SCHEMBL10457952 0.80 RAB9A (0.48) HTTNPC1RAB9AGLASMN1; SMN2
SCHEMBL1806526 0.79 OPRM1 (0.44) HTTALDH1A1MAPTLMNA
SCHEMBL7514017 0.79 NPC1 (0.44) HTTNPC1RAB9ATDP1GLA
SCHEMBL7514022 0.79 NPC1 (0.44) HTTNPC1RAB9ATDP1GLA
SCHEMBL11034119 0.78 MAOB (0.44) HTTNPC1RAB9ATDP1SMN1; SMN2
SCHEMBL22994501 0.75 SMN1; SMN2 (0.70) HTTTDP1GLACYP1A2HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260001924-A1 NEMO COILED COIL MIMICS AND METHODS OF USING SAME NEW YORK UNIVERSITY (US) 2026-01-01 — — US disclosed
US-12371461-B2 Nemo coiled coil mimics and methods of using same NEW YORK UNIVERSITY (US) 2025-07-29 — — US disclosed
EP-3303367-B1 STABILIZED MINIMAL COILED-COIL MIMETICS UNIV NEW YORK (US) 2025-06-18 — — EP disclosed
WO-2024130161-A2 NOVEL CAMPTOTHECIN DERIVATIVES AND CONJUGATES THEREOF BIONECURE THERAPEUTICS INC (US) 2024-06-20 — — WO disclosed
US-20240190930-A1 NEMO COILED COIL MIMICS AND METHODS OF USING SAME UNIV NEW YORK (US) 2024-06-13 — — US disclosed
US-11891422-B2 NEMO coiled coil mimics and methods of using same NEW YORK UNIVERSITY (US) 2024-02-06 — — US disclosed
US-20240034753-A1 THERAPEUTIC PEPTIDES COHBAR, INC. 2024-02-01 — — US disclosed
US-11753445-B2 Therapeutic peptides COHBAR, INC. (US) 2023-09-12 — — US disclosed
US-20230218710-A1 METHOD OF TREATING CORONAVIRUS INFECTIONS COHBAR, INC. 2023-07-13 — — US disclosed
US-20230137562-A1 TAU AGGREGATION INHIBITORS ADRX, INC. 2023-05-04 — — US disclosed
US-20200062804-A1 PEPTIDE INHIBITORS OF TRANSCRIPTION FACTOR AGGREGATION ADRX, INC. 2020-02-27 — — US disclosed
EP-3519431-A1 THERAPEUTIC MOTS-C RELATED PEPTIDES Cohbar Inc. (US) 2019-08-07 — — EP disclosed
WO-2019036725-A2 TAU AGGREGATION PEPTIDE INHIBITORS ADRX, INC. (US) 2019-02-21 — — WO disclosed
WO-2018226992-A1 TAU AGGREGATION INHIBITORS ADRX, INC. (US) 2018-12-13 — — WO disclosed
WO-2018156892-A1 PEPTIDE INHIBITORS OF TRANSCRIPTION FACTOR AGGREGATION ADRX, INC. (US) 2018-08-30 — — WO disclosed
US-20180162907-A1 STABILIZED MINIMAL COILED-COIL MIMETICS NEW YORK UNIVERSITY 2018-06-14 — — US disclosed
EP-3303367-A1 STABILIZED MINIMAL COILED-COIL MIMETICS New York University (US) 2018-04-11 — — EP disclosed
WO-2018064098-A1 THERAPEUTIC MOTS-C RELATED PEPTIDES COHBAR, INC. (US) 2018-04-05 — — WO disclosed
WO-2016201007-A1 STABILIZED MINIMAL COILED-COIL MIMETICS NEW YORK UNIVERSITY (US) 2016-12-15 — — WO disclosed
US-20150218137-A1 PYRAZOLYL-UREAS AS KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2015-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12371461-B2 Nemo coiled coil mimics and methods of using same COIL, CALCOCO2, NCAPH HTT 1866/4885NPC1 503/4885RAB9A 4061/4885
US-20150218137-A1 PYRAZOLYL-UREAS AS KINASE INHIBITORS SYK, BTK, LYN HTT 4479/4885NPC1 4818/4885RAB9A 703/4885
US-20260001924-A1 NEMO COILED COIL MIMICS AND METHODS OF USING SAME DDX21, PHAX, RBX1 HTT 1910/4885NPC1 1544/4885RAB9A 3652/4885
US-11891422-B2 NEMO coiled coil mimics and methods of using same COIL, CALCOCO2, NCAPH HTT 1866/4885NPC1 503/4885RAB9A 4061/4885
US-20180162907-A1 STABILIZED MINIMAL COILED-COIL MIMETICS COIL, CALCOCO2, CRYZ HTT 457/4885NPC1 1980/4885RAB9A 3772/4885
US-20240190930-A1 NEMO COILED COIL MIMICS AND METHODS OF USING SAME COIL, CALCOCO2, NCAPH HTT 1871/4885NPC1 518/4885RAB9A 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.