Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082129 | 0.80 | ALDH1A1 (0.38) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL7958200 | 0.80 | MMP12 (0.38) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL859012 | 0.80 | MMP12 (0.38) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL15979057 | 0.80 | NR3C2 (0.39) | MMP12CYP11B1CYP11B2NR3C2 | |
| SCHEMBL10283759 | 0.80 | MMP12 (0.49) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL17095009 | 0.78 | PARP1 (0.37) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL7326455 | 0.76 | PARP1 (0.39) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL13658043 | 0.76 | TRPV1 (0.40) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL21382790 | 0.76 | GRM5 (0.36) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 | |
| SCHEMBL13748940 | 0.76 | MMP12 (0.39) | MMP12CYP11B1CYP11B2PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-B1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS INC (US) | 2016-12-14 | — | — | EP | disclosed |