Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26129785 | 0.88 | RAPGEF4 (0.65) | RAPGEF4MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL28286411 | 0.77 | TAS2R14 (0.54) | RAPGEF4TAS2R14AKR1C3AKR1C2P2RX1 | |
| SCHEMBL18299613 | 0.76 | FFAR4 (0.56) | MEN1ALDH1A1MAPTKMT2AGAA | |
| SCHEMBL7715418 | 0.73 | ALDH1A1 (0.47) | RAPGEF4MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15312216 | 0.72 | RAPGEF4 (0.49) | RAPGEF4MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL16481381 | 0.71 | AKR1C3 (0.62) | RAPGEF4MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL503577 | 0.69 | RAPGEF4 (0.72) | RAPGEF4NPSR1 | |
| SCHEMBL9312386 | 0.69 | RAPGEF4 (0.54) | RAPGEF4MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL28868421 | 0.69 | RAPGEF4 (0.68) | RAPGEF4TAS2R14 | |
| Diphenylamine SCHEMBL31175856 | 0.68 | ALDH1A1 (0.70) | MEN1ALDH1A1MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160362370-A1 | NUCLEAR RECEPTOR MODULATORS | ABBVIE INC. (US) | 2016-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362370-A1 | NUCLEAR RECEPTOR MODULATORS | NR1I2, NR1H2, NR5A2 | RAPGEF4 1471/4885MEN1 3616/4885ALDH1A1 940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.