Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18308333 | 0.85 | LCK (0.32) | MAPT | |
| SCHEMBL18308505 | 0.83 | MAPT (0.34) | MAPT | |
| SCHEMBL18308325 | 0.83 | KDM4E (0.35) | MAPTKMT2AALDH1A1MEN1 | |
| SCHEMBL18308389 | 0.75 | MET (0.34) | PDE10ACYP1A2TSHR | |
| SCHEMBL18308554 | 0.74 | BRD4 (0.32) | PDE10ACYP1A2CYP3A4 | |
| SCHEMBL18308391 | 0.73 | BRD4 (0.31) | CYP3A4 | |
| SCHEMBL20373441 | 0.64 | PDE4A (0.39) | HSD17B10KMT2AGAATSHRALDH1A1 | |
| SCHEMBL20373281 | 0.63 | RECQL (0.38) | RECQLLMNAMAPTKMT2ACYP1A2 | |
| SCHEMBL18308477 | 0.58 | ALDH1A1 (0.44) | RECQLHSD17B10LMNAMAPTCYP3A4 | |
| SCHEMBL10951358 | 0.58 | HSD17B10 (0.46) | RECQLHSD17B10LMNAKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |