Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.63 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.59 |
| ▸ | APP | P05067 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HNF4A | P41235 | 2/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18311412 | 0.96 | ALOX5 (0.68) | ALOX5ACMSDAPPHDAC2HDAC4 | |
| SCHEMBL18311410 | 0.96 | ALOX5 (0.68) | ALOX5ACMSDAPPHDAC2HDAC4 | |
| SCHEMBL20854606 | 0.79 | HDAC4 (0.50) | ALOX5ACMSDHDAC2HDAC4HDAC8 | |
| SCHEMBL28134269 | 0.79 | ALOX5 (0.91) | ALOX5ACMSDAPPHNF4ADHFR | |
| SCHEMBL928289 | 0.78 | ALOX5 (1.00) | ALOX5ACMSDAPPHNF4ADHFR | |
| SCHEMBL29848221 | 0.78 | ALOX5 (1.00) | ALOX5ACMSDAPPHNF4ADHFR | |
| Formaldehyde SCHEMBL28374238 | 0.77 | ALOX5 (0.86) | ALOX5ACMSDAPPHDAC2HDAC4 | |
| SCHEMBL21471507 | 0.77 | HDAC4 (0.69) | ALOX5ACMSDAPPHDAC2HDAC4 | |
| Bicarbonate SCHEMBL11789771 | 0.77 | ALOX5 (0.86) | ALOX5ACMSDAPPHDAC2HDAC4 | |
| SCHEMBL18311419 | 0.77 | HDAC4 (0.49) | ALOX5ACMSDHDAC2HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307256-B1 | HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITIS B | UNIV SAINT LOUIS (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2016201243-A1 | HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITS B AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2016-12-15 | — | — | WO | disclosed |