Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.68 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.57 |
| ▸ | HNF4A | P41235 | 2/20 | 0.57 |
| ▸ | DHFR | P00374 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18311410 | 1.00 | ALOX5 (0.68) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| SCHEMBL18311411 | 0.96 | ALOX5 (0.63) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| SCHEMBL928289 | 0.81 | ALOX5 (1.00) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| SCHEMBL29848221 | 0.81 | ALOX5 (1.00) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| Formaldehyde SCHEMBL28374238 | 0.80 | ALOX5 (0.86) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| Bicarbonate SCHEMBL11789771 | 0.80 | ALOX5 (0.86) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| SCHEMBL27714322 | 0.79 | ALOX5 (0.95) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| Methane SCHEMBL28271157 | 0.79 | ALOX5 (0.95) | ALOX5ACMSDHNF4ADHFRMCL1 | |
| SCHEMBL18311413 | 0.79 | QDPR (0.70) | ALOX5KDM4ELMNAMAPTAPP | |
| Sulfur Dioxide SCHEMBL22500872 | 0.78 | ALOX5 (0.83) | ALOX5ACMSDHNF4ADHFRMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307256-B1 | HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITIS B | UNIV SAINT LOUIS (US) | 2023-06-07 | — | — | EP | disclosed |
| US-10980754-B2 | Anti-fungal compounds | SAINT LOUIS UNIVERSITY (US) | 2021-04-20 | — | — | US | disclosed |
| US-10980754-B2 | Anti-fungal compounds | SAINT LOUIS UNIVERSITY (US) | 2021-04-20 | — | — | US | disclosed |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2019-04-04 | — | — | US | disclosed |
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2019-04-04 | — | — | US | disclosed |
| WO-2017184752-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2017184752-A1 | ANTI-FUNGAL COMPOUNDS | SAINT LOUIS UNIVERSITY (US) | 2017-10-26 | — | — | WO | disclosed |
| WO-2016201243-A1 | HYDROXYLATED TROPOLONE INHIBITORS OF NUCLEOTIDYL TRANSFERASES IN HERPESVIRUS AND HEPATITS B AND USES THEREFOR | SAINT LOUIS UNIVERSITY (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190099385-A1 | ANTI-FUNGAL COMPOUNDS | ERG28, NANS, DPM1 | ALOX5 3669/4885ACMSD 668/4885HNF4A 4055/4885 |
| US-10980754-B2 | Anti-fungal compounds | ERG28, NANS, DPM1 | ALOX5 3669/4885ACMSD 668/4885HNF4A 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.