Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18311997 | 0.91 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18312071 | 0.85 | POLB (0.55) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL8211 | 0.84 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL16506188 | 0.84 | POLB (0.60) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18311992 | 0.84 | POLB (0.51) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18312196 | 0.84 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18311999 | 0.81 | AHR (0.44) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18312124 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18312268 | 0.78 | KDM4E (0.60) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 | |
| SCHEMBL18312135 | 0.78 | NFKB1 (0.47) | ALDH1A1SMN1; SMN2MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118707-A1 | BETA-NAPHTHOISOFLAVONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | THESAN PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | US | disclosed |
| US-20180118707-A1 | BETA-NAPHTHOISOFLAVONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | THESAN PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | US | disclosed |
| WO-2016200817-A1 | BETA-NAPHTHOISOFLAVONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | THESAN PHARMACEUTICALS, INC. (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118707-A1 | BETA-NAPHTHOISOFLAVONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | AHR, ARNT, NR1H2 | ALDH1A1 318/4885SMN1; SMN2 3434/4885MAPT 3748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.