Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 5/20 | 0.63 |
| ▸ | ATXN2 | Q99700 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | GPR183 | P32249 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23123044 | 0.80 | ALDH1A1 (0.48) | ENPP2ATXN2CYP3A4USP2ALDH1A1 | |
| SCHEMBL15540638 | 0.78 | ENPP2 (1.00) | ENPP2ATXN2 | |
| SCHEMBL18315558 | 0.77 | CA12 (0.60) | ENPP2ATXN2 | |
| SCHEMBL23123111 | 0.77 | IP6K1 (0.43) | ENPP2ATXN2CYP3A4USP2ALDH1A1 | |
| SCHEMBL15540286 | 0.77 | ATXN2 (1.00) | ENPP2ATXN2 | |
| SCHEMBL18315539 | 0.76 | ENPP2 (0.58) | ENPP2ATXN2CYP3A4USP2ALDH1A1 | |
| SCHEMBL23123113 | 0.76 | USP2 (0.47) | CYP3A4USP2ALDH1A1CYP2D6HIF1A | |
| SCHEMBL5924169 | 0.75 | HPGD (0.58) | CYP3A4ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL5924363 | 0.74 | HPGD (0.61) | CYP3A4ALDH1A1CYP2D6CYP1A2TSHR | |
| SCHEMBL15541236 | 0.73 | ENPP2 (0.60) | ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861566-B1 | NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE | HOFFMANN LA ROCHE (CH) | 2016-12-21 | — | — | EP | claimed |