Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 6/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19743463 | 0.88 | HIF1A (0.43) | LIPGROCK1LPLP4HBF11 | |
| SCHEMBL18497287 | 0.84 | AAK1 (0.40) | LIPGROCK1AAK1LPLP4HB | |
| SCHEMBL20296811 | 0.83 | AAK1 (0.47) | LIPGROCK1AAK1HIF1AMEN1 | |
| SCHEMBL17418789 | 0.83 | ROCK1 (0.53) | LIPGROCK1LPLP4HBF11 | |
| SCHEMBL1684669 | 0.80 | LIPG (0.53) | LIPGLPLP4HBF11F2 | |
| SCHEMBL20528016 | 0.79 | HIF1A (0.40) | LIPGROCK1AAK1LPLP4HB | |
| SCHEMBL30159287 | 0.79 | LIPG (0.42) | LIPGROCK1AAK1LPLF11 | |
| SCHEMBL16831556 | 0.79 | LIPG (0.42) | LIPGROCK1AAK1LPLF11 | |
| SCHEMBL4604189 | 0.77 | LIPG (0.52) | LIPGLPLP4HBMEN1KMT2A | |
| SCHEMBL21179837 | 0.76 | AAK1 (0.40) | LIPGROCK1AAK1LPLF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307719-A1 | NRF2 REGULATORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016203400-A1 | NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-12-22 | — | — | WO | disclosed |