Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.49 |
| ▸ | GLB1 | P16278 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10849451 | 0.86 | MAPK1 (0.49) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL19834811 | 0.85 | TSHR (0.47) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL1936670 | 0.85 | ALDH1A1 (0.51) | FUCA1TSHRMAPTHTTMAPK1 | |
| SCHEMBL18322314 | 0.83 | FUCA1 (0.46) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL13365129 | 0.83 | CYP4F2 (0.48) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL18334195 | 0.82 | TTR (0.66) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL27883874 | 0.80 | L3MBTL1 (0.48) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL11717491 | 0.80 | KDM4E (0.48) | FUCA1GLB1TSHRMAPTHTT | |
| SCHEMBL8629493 | 0.79 | TSHR (0.48) | FUCA1GLB1TSHRMAPTMAPK1 | |
| SCHEMBL4470672 | 0.79 | ALDH1A1 (0.59) | TSHRMAPTHTTMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307723-B1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | BSIM THERAPEUTICS S A (PT) | 2020-11-11 | — | — | EP | disclosed |
| EP-3307723-B1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | BSIM THERAPEUTICS S A (PT) | 2020-11-11 | — | — | EP | disclosed |
| US-10377729-B2 | Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) | BSIM THERAPEUTICS, S.A. (PT) | 2019-08-13 | — | — | US | disclosed |
| US-10377729-B2 | Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) | BSIM THERAPEUTICS, S.A. (PT) | 2019-08-13 | — | — | US | disclosed |
| US-20180208570-A1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | BSIM2 - Biomolecular Simulations, S.A. (PT) | 2018-07-26 | — | — | US | disclosed |
| US-20180208570-A1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | BSIM2 - Biomolecular Simulations, S.A. (PT) | 2018-07-26 | — | — | US | disclosed |
| EP-3307723-A1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | BSIM2 - Biomolecular Simulations, S.A. (PT) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016203402-A1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | BSIM2 – BIOMOLECULAR SIMULATIONS LDA (PT) | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208570-A1 | BIS-FURAN DERIVATIVES AS TRANSTHYRETIN (TTR) STABILIZERS AND AMYLOID INHIBITORS FOR THE TREATMENT OF FAMILIAL AMYLOID POLYNEUROPATHY (FAP) | TTR, FAP, PSEN1 | FUCA1 419/4885GLB1 2813/4885TSHR 2567/4885 |
| US-10377729-B2 | Bis-furan derivatives as transthyretin (TTR) stabilizers and amyloid inhibitors for the treatment of familial amyloid polyneuropathy (FAP) | TTR, FAP, PSEN1 | FUCA1 419/4885GLB1 2813/4885TSHR 2567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.