Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17988794 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL16934666 | 0.74 | ADH1A (0.38) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL16781591 | 0.74 | ALDH1A1 (0.35) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL16877013 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL5271364 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL2460600 | 0.73 | ALDH1A1 (0.37) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL17988820 | 0.72 | KDM4E (0.33) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL3824654 | 0.71 | HTR2A (0.36) | KDM4EALDH1A1MAPTTSHRTDP1 | |
| SCHEMBL179056 | 0.70 | KDM4E (0.36) | KDM4EALDH1A1MAPTHSD17B10TSHR | |
| SCHEMBL12776570 | 0.69 | KDM4E (0.47) | KDM4EALDH1A1MAPTHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307780-A1 | ANTIBODIES AND IMMUNOCONJUGATES | Genentech, Inc. (US) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016205176-A1 | ANTIBODIES AND IMMUNOCONJUGATES | GENENTECH, INC. (US) | 2016-12-22 | — | — | WO | disclosed |