Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9129321 | 0.81 | ABL1 (0.47) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL30714096 | 0.80 | HPGD (0.58) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL12433169 | 0.80 | HPGD (0.58) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL19006400 | 0.78 | KMT2A (0.44) | LMNAALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL2205686 | 0.75 | HPGD (0.40) | ALDH1A1MAPTHPGDSMN1; SMN2TDP1 | |
| SCHEMBL22200728 | 0.74 | HPGD (0.37) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL13870189 | 0.74 | MAPT (0.58) | ALDH1A1MAPTHPGDSMN1; SMN2TDP1 | |
| SCHEMBL31337359 | 0.71 | ABL1 (0.43) | LMNAALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL7860044 | 0.71 | POLB (0.40) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL22200565 | 0.70 | L3MBTL1 (0.36) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737815-B1 | THIO-SUBSTITUTED BIARYL-METHANESULFINYL DERIVATIVES | CEPHALON INC (US) | 2016-12-21 | — | — | EP | disclosed |