Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.48 |
| ▸ | TUBB | P07437 | 3/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324967 | 0.92 | GAA (0.60) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL18325958 | 0.86 | KMT2A (0.64) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL3965268 | 0.84 | GAA (0.83) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL29405348 | 0.78 | CYP1A2 (0.65) | GAAMEN1KMT2ATSHRNFKB1 | |
| SCHEMBL347472 | 0.78 | CYP1A2 (0.65) | GAAMEN1KMT2ATSHRNFKB1 | |
| SCHEMBL16389390 | 0.78 | GAA (0.64) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL7029677 | 0.77 | CYP3A4 (0.62) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL29699330 | 0.76 | GAA (1.00) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL347877 | 0.76 | GAA (1.00) | GAAMEN1KMT2AMAPTHPGD | |
| SCHEMBL30388881 | 0.76 | GAA (0.75) | GAAMEN1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368886-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | UNIVERSITA' DEGLI STUDI DI SIENA (IT) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368886-A1 | MULTITARGET HEDGEHOG PATHWAY INHIBITORS AND USES THEREOF | SHH, GLI1, SMO | GAA 1875/4885MEN1 387/4885KMT2A 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.