Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | CD44 | P16070 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18325442 | 1.00 | PNMT (0.50) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL12635734 | 0.80 | PNMT (0.43) | PNMTCD44MAOBHTR2CHTR2A | |
| SCHEMBL18325505 | 0.77 | PNMT (0.46) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL18325510 | 0.77 | PNMT (0.46) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL23097091 | 0.74 | PNMT (0.43) | PNMTCD44MAOBHTR2CMEN1 | |
| SCHEMBL21447810 | 0.73 | BRD4 (0.40) | HTR2CHTR2BHTR2AMEN1KMT2A | |
| SCHEMBL22512904 | 0.73 | PNMT (0.46) | PNMTCD44MAOBHTR2CHTR2B | |
| SCHEMBL29978110 | 0.73 | PLAU (0.56) | MAOBPLAU | |
| SCHEMBL15147099 | 0.73 | PLAU (0.56) | MAOBPLAU | |
| SCHEMBL598142 | 0.73 | PLAU (0.56) | MAOBPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016202253-A1 | NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-12-22 | — | — | WO | disclosed |