SCHEMBL18328366

SCHEMBL18328366

O=S(=O)(NC(CCl)Cc1ccccc1)c1ccc(S)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.56
CA7 P43166 2/20 0.56
PIN1 Q13526 1/20 0.51
MMP2 P08253 9/20 0.49
MMP9 P14780 7/20 0.49
ADAMTS4 O75173 1/20 0.49
CTSL P07711 1/20 0.47
CTSS P25774 1/20 0.47
CA1 P00915 1/20 0.47
CA4 P22748 1/20 0.47
CA9 Q16790 1/20 0.47
ADAMTS5 Q9UNA0 1/20 0.47
ALDH1A1 P00352 3/20 0.44
MAPT P10636 1/20 0.44
MMP1 P03956 1/20 0.44
MMP3 P08254 1/20 0.44
MMP7 P09237 1/20 0.44
MMP13 P45452 1/20 0.44
NEK1 Q96PY6 2/20 0.43
CYP1A2 P05177 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18321207 0.87 CA2 (0.73) CA2CA7PIN1MMP2MMP9
SCHEMBL28981623 0.80 CA2 (0.63) CA2CA7MMP2MMP9ADAMTS4
SCHEMBL28981627 0.80 CA2 (0.63) CA2CA7MMP2MMP9ADAMTS4
SCHEMBL7246631 0.76 PIN1 (0.57) CA2CA7PIN1MMP2MMP9
SCHEMBL7246633 0.76 PIN1 (0.57) CA2CA7PIN1MMP2MMP9
SCHEMBL1287449 0.75 MMP2 (0.62) CA2CA7PIN1MMP2MMP9
SCHEMBL1287447 0.75 MMP2 (0.62) CA2CA7PIN1MMP2MMP9
SCHEMBL8532716 0.75 PIN1 (0.59) CA2CA7PIN1MMP2MMP9
Bromide SCHEMBL27546307 0.75 PIN1 (0.56) CA2CA7PIN1MMP2MMP9
SCHEMBL9512132 0.73 MMP2 (0.60) CA2CA7PIN1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016202894-A1 METHOD OF CONVERTING ALCOHOL TO HALIDE UNIVERSITAET DES SAARLANDES (DE) 2016-12-22 WO disclosed