Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mandelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mandelic Acid SCHEMBL1672106 | 0.92 | LMNA (0.78) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL8744861 | 0.92 | LMNA (0.78) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28803140 | 0.90 | LMNA (0.82) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL26611028 | 0.90 | LMNA (0.82) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL9393798 | 0.88 | LMNA (0.72) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28177337 | 0.86 | LMNA (0.69) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL29287647 | 0.86 | LMNA (0.75) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28014619 | 0.86 | LMNA (0.75) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL8876737 | 0.85 | LMNA (0.90) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL6056301 | 0.85 | LMNA (0.90) | LMNAMAPK1CES2CES1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328220-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8992798-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-8784686-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2014-07-22 | — | — | US | disclosed |
| US-20140187684-A1 | LIQUIDS | INNOVIA FILMS LIMITED (GB) | 2014-07-03 | — | — | US | disclosed |
| US-20110257433-A1 | LIQUIDS | THE UNIVERSITY OF YORK (GB) | 2011-10-20 | — | — | US | disclosed |
| EP-2322497-A1 | Ionic liquids comprising nitrogen containing cations | Innovia Films Limited (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | disclosed |
| US-4234599-A | Treatment of skin keratoses with α-hydroxy acids and related compounds | SCOTT EUGENE J VAN | 1980-11-18 | — | — | US | disclosed |