Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Mandelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.47 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mandelic Acid SCHEMBL1672106 | 1.00 | LMNA (0.78) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL9393798 | 0.92 | LMNA (0.72) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL1832889 | 0.92 | LMNA (0.72) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28177337 | 0.90 | LMNA (0.69) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL29287647 | 0.89 | LMNA (0.75) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28014619 | 0.89 | LMNA (0.75) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL6056301 | 0.89 | LMNA (0.90) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL8876737 | 0.89 | LMNA (0.90) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL29777368 | 0.89 | LMNA (1.00) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL21647917 | 0.89 | LMNA (1.00) | LMNAMAPK1CES2CES1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240096440-A1 | RATIONAL DESIGN OF MICROBIAL-BASED BIOTHERAPEUTICS | GUSTO GLOBAL, LLC | 2024-03-21 | — | — | US | disclosed |
| US-11810650-B2 | Rational design of microbial-based biotherapeutics | GUSTO GLOBAL, LLC (US) | 2023-11-07 | — | — | US | disclosed |
| EP-3606325-A1 | RATIONAL DESIGN OF MICROBIAL-BASED BIOTHERAPEUTICS | Gusto Global, LLC (US) | 2020-02-12 | — | — | EP | disclosed |
| WO-2018187272-A1 | RATIONAL DESIGN OF MICROBIAL-BASED BIOTHERAPEUTICS | GUSTO GLOBAL, LLC (US) | 2018-10-11 | — | — | WO | disclosed |
| EP-0353714-B1 | Silver halide photographic photosensitive materials | FUJI PHOTO FILM CO LTD (JP) | 1997-01-22 | — | — | EP | disclosed |
| US-5118596-A | Triaza-, tetraaza- or pentaazaindene compound with blocked bleach accelerating agent | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| EP-0353714-A2 | Silver halide photographic photosensitive materials | FUJI PHOTO FILM CO., LTD. (JP) | 1990-02-07 | — | — | EP | disclosed |