Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Mandelic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.47 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mandelic Acid SCHEMBL8744861 | 1.00 | LMNA (0.78) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL9393798 | 0.92 | LMNA (0.72) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL1832889 | 0.92 | LMNA (0.72) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28177337 | 0.90 | LMNA (0.69) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL29287647 | 0.89 | LMNA (0.75) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL28014619 | 0.89 | LMNA (0.75) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL6056301 | 0.89 | LMNA (0.90) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL8876737 | 0.89 | LMNA (0.90) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL29777368 | 0.89 | LMNA (1.00) | LMNAMAPK1CES2CES1SRC | |
| Mandelic Acid SCHEMBL21647917 | 0.89 | LMNA (1.00) | LMNAMAPK1CES2CES1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592425-A | Modified seaweed functional water-soluble fertilizer and preparation method thereof | 青岛埃图生物科技有限公司 | 2020-08-28 | — | — | CN | claimed |
| CN-111302869-A | Modified humic acid functional water-soluble fertilizer and preparation method thereof | 青岛埃图作物营养有限公司 | 2020-06-19 | — | — | CN | claimed |
| CN-109134044-A | Particle a great number of elements Water soluble fertilizer and preparation method thereof | 青岛埃图作物营养有限公司 | 2019-01-04 | — | — | CN | claimed |
| US-20140227366-A1 | CARRIER MATERIAL FOR IMPROVING THE PERSISTANCE OF BIOCIDES | ARPOLITH GMBH (DE) | 2014-08-14 | — | — | US | claimed |
| US-11993810-B2 | Chromogenic peroxidase substrates | AGILENT TECHNOLOGIES, INC. (US) | 2024-05-28 | — | — | US | disclosed |
| EP-4336184-A2 | CHROMOGENIC PEROXIDASE SUBSTRATES | Agilent Technologies, Inc. (A Delaware Corporation) (US) | 2024-03-13 | — | — | EP | disclosed |
| EP-3391056-B1 | CHROMOGENIC PEROXIDASE SUBSTRATES | AGILENT TECHNOLOGIES INC (US) | 2024-01-17 | — | — | EP | disclosed |
| US-20230002816-A1 | CHROMOGENIC PEROXIDASE SUBSTRATES | DAKO DENMARK APS (DK) | 2023-01-05 | — | — | US | disclosed |
| US-11466314-B2 | Chromogenic peroxidase substrates | AGILENT TECHNOLOGIES, INC. (US) | 2022-10-11 | — | — | US | disclosed |
| CN-114315783-A | Chromogenic peroxidase substrates | 安捷伦科技有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-20220024992-A1 | COMPOSITIONS AND METHODS COMPRISING LYSOCINS AS BIOENGINEERED ANTIMICROBIALS FOR USE IN TARGETING GRAM-NEGATIVE BACTERIA | UNIV ROCKEFELLER (US) | 2022-01-27 | — | — | US | disclosed |
| CN-108369235-B | Chromogenic peroxidase substrates | 丹麦科达有限公司 | 2021-11-26 | — | — | CN | disclosed |
| US-20100240085-A1 | CONJUGATE MOLECULES | DAKO DENMARK APS (DK) | 2010-09-23 | — | — | US | disclosed |
| CN-101836117-A | Rapid and sensitive method for detecting biological targets | DAKO DENMARK AS | 2010-09-15 | — | — | CN | disclosed |
| WO-2010094284-A1 | METHODS AND COMPOUNDS FOR DETECTION OF MOLECULAR TARGETS | DAKO DENMARK A/S (DK) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010094283-A1 | CONJUGATE MOLECULES | DAKO DENMARK A/S (DK) | 2010-08-26 | — | — | WO | disclosed |
| EP-2201058-A2 | A RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS | Dako Denmark A/S (DK) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009036760-A2 | A RAPID AND SENSITIVE METHOD FOR DETECTION OF BIOLOGICAL TARGETS | DAKO DENMARK A/S (DK) | 2009-03-26 | — | — | WO | disclosed |
| US-4746507-A | ETHYLENEDIAMINE HYDROXYPHENYLACETIC ACID, NUCLEAR MAGNETIC RESONANCE | SALUTAR, INC. (US) | 1988-05-24 | — | — | US | disclosed |
| US-4746507-A | ETHYLENEDIAMINE HYDROXYPHENYLACETIC ACID, NUCLEAR MAGNETIC RESONANCE | SALUTAR, INC. (US) | 1988-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11466314-B2 | Chromogenic peroxidase substrates | MPO, TPO, TYR | LMNA 3612/4885MAPK1 3439/4885CES2 32/4885 |
| US-11993810-B2 | Chromogenic peroxidase substrates | MPO, TPO, TYR | LMNA 3612/4885MAPK1 3439/4885CES2 32/4885 |
| US-20230002816-A1 | CHROMOGENIC PEROXIDASE SUBSTRATES | MPO, TPO, TYR | LMNA 3612/4885MAPK1 3439/4885CES2 32/4885 |
| US-20140227366-A1 | CARRIER MATERIAL FOR IMPROVING THE PERSISTANCE OF BIOCIDES | BSG, PGLS, GUSB | LMNA 3766/4885MAPK1 4845/4885CES2 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.