Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29015992 | 0.78 | SIGMAR1 (0.46) | IDO1BCHE | |
| SCHEMBL18329401 | 0.78 | KDM4E (0.42) | NPC1RAB9AALDH1A1HPGDADRB2 | |
| SCHEMBL21509980 | 0.77 | BCHE (0.44) | NPC1RAB9ACTSSCTSKIDO1 | |
| SCHEMBL24672519 | 0.77 | TDP1 (0.48) | BCHE | |
| SCHEMBL38663029 | 0.76 | GRM4 (0.45) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL21645721 | 0.75 | MAPT (0.40) | CASP3SENP7SENP6PTPN1ERCC5 | |
| SCHEMBL21645720 | 0.75 | MAPT (0.40) | CASP3SENP7SENP6PTPN1ERCC5 | |
| SCHEMBL21645653 | 0.75 | CTSS (0.44) | CASP3SENP7SENP6PTPN1ERCC5 | |
| SCHEMBL21645651 | 0.75 | CTSS (0.44) | CASP3SENP7SENP6PTPN1ERCC5 | |
| SCHEMBL18329404 | 0.74 | ALDH1A1 (0.59) | PTPN1NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10426784-B2 | Imidazodiazepine compound | ASTELLAS PHARMA INC. (JP) | 2019-10-01 | — | — | US | disclosed |
| EP-3312181-B1 | IMIDAZODIAZEPINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2019-08-07 | — | — | EP | disclosed |
| US-20180185383-A1 | IMIDAZODIAZEPINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2018-07-05 | — | — | US | disclosed |
| EP-3312181-A1 | IMIDAZODIAZEPINE COMPOUND | Astellas Pharma Inc. (JP) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016204268-A1 | IMIDAZODIAZEPINE COMPOUND | アステラス製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180185383-A1 | IMIDAZODIAZEPINE COMPOUND | HTR1D, DRD2, DRD1 | CASP3 4022/4885SENP7 4086/4885SENP6 4433/4885 |
| US-10426784-B2 | Imidazodiazepine compound | GRIN2D, HTR1D, DRD2 | CASP3 4119/4885SENP7 4280/4885SENP6 4604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.