Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10310604 | 0.82 | EPHX2 (0.43) | ALDH1A1MEN1KMT2AHPGDGAA | |
| SCHEMBL11989435 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL20311441 | 0.77 | CYP3A4 (0.58) | ALDH1A1KMT2AHPGDPOLBGAA | |
| SCHEMBL10627932 | 0.77 | CA2 (0.38) | MEN1KMT2AHPGDPOLBGAA | |
| SCHEMBL16368739 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL16435174 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL11955634 | 0.76 | EPHX2 (0.39) | ALDH1A1MEN1KMT2AHPGDGAA | |
| SCHEMBL10310589 | 0.76 | LIPE (0.40) | ALDH1A1MEN1KMT2AHPGDPOLB | |
| SCHEMBL2606047 | 0.75 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AHPGDNPC1 | |
| SCHEMBL13901271 | 0.74 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2AHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368930-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368930-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | KRAS, HRAS, NRAS | ALDH1A1 2792/4885MEN1 2804/4885KMT2A 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.