Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 17/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | ATF4 | P18848 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15337719 | 0.86 | EPHX2 (0.59) | EPHX2EPHX1ATF4 | |
| SCHEMBL18330454 | 0.83 | USP2 (0.47) | — | |
| SCHEMBL12440445 | 0.82 | USP2 (0.54) | ATF4 | |
| SCHEMBL18330481 | 0.81 | L3MBTL1 (0.49) | EPHX2EPHX1 | |
| SCHEMBL25930914 | 0.81 | EPHX2 (0.64) | EPHX2EPHX1 | |
| SCHEMBL13627860 | 0.80 | ALDH1A1 (0.50) | EPHX2EPHX1ATF4 | |
| SCHEMBL20381570 | 0.80 | ALDH1A1 (0.50) | EPHX2EPHX1ATF4 | |
| SCHEMBL6003218 | 0.79 | NPSR1 (0.65) | EPHX1 | |
| SCHEMBL12438989 | 0.79 | NPSR1 (0.59) | EPHX1 | |
| SCHEMBL19002252 | 0.78 | EPHX2 (0.60) | EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368930-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368930-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | KRAS, HRAS, NRAS | EPHX2 2775/4885EPHX1 2274/4885ATF4 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.