Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29762300 | 0.93 | ADRA1A (0.49) | ADRA1AADRA1DADRA1BSIGMAR1SLC2A1 | |
| SCHEMBL23632922 | 0.93 | ADRA1A (0.49) | ADRA1AADRA1DADRA1BSIGMAR1SLC2A1 | |
| SCHEMBL28976177 | 0.93 | ADRA1A (0.49) | ADRA1AADRA1DADRA1BSIGMAR1SLC2A1 | |
| SCHEMBL18330968 | 0.90 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BSIGMAR1CCR5 | |
| SCHEMBL28969319 | 0.84 | PDK1 (0.50) | ADRA1ASIGMAR1KMT2AMEN1LMNA | |
| SCHEMBL30211156 | 0.84 | PDK1 (0.50) | ADRA1ASIGMAR1KMT2AMEN1LMNA | |
| SCHEMBL23958491 | 0.84 | PDK1 (0.50) | ADRA1ASIGMAR1KMT2AMEN1LMNA | |
| SCHEMBL30131020 | 0.82 | ADRA1D (0.42) | ADRA1AADRA1DADRA1BSIGMAR1SLC2A1 | |
| SCHEMBL28976196 | 0.82 | ADRA1D (0.42) | ADRA1AADRA1DADRA1BSIGMAR1SLC2A1 | |
| SCHEMBL26456935 | 0.82 | ADRA1D (0.42) | ADRA1AADRA1DADRA1BSIGMAR1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10385060-B2 | Piperidine derivative and preparation method and pharmaceutical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-08-20 | — | — | US | disclosed |
| US-20180170943-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-06-21 | — | — | US | disclosed |
| US-20180170943-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-06-21 | — | — | US | disclosed |
| EP-3312184-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016202161-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385060-B2 | Piperidine derivative and preparation method and pharmaceutical use thereof | GPER1, CYP19A1, PGR | ADRA1A 136/4885ADRA1D 46/4885ADRA1B 130/4885 |
| US-20180170943-A1 | PIPERIDINE DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | GPER1, CYP19A1, PGR | ADRA1A 136/4885ADRA1D 46/4885ADRA1B 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.