Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 8/20 | 0.51 |
| ▸ | MMP2 | P08253 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131132 | 0.87 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL7681890 | 0.83 | ALDH1A1 (0.70) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL18332181 | 0.82 | APEX1 (0.51) | ALDH1A1HPGDKDM4ELMNAMAPT | |
| SCHEMBL656156 | 0.79 | KDM4E (0.67) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL394554 | 0.79 | ALOX15 (0.64) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL4049040 | 0.78 | ALOX15 (0.66) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL18332191 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9650786 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13345538 | 0.77 | KDM4E (0.63) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1277858 | 0.76 | RAB9A (0.52) | ALDH1A1HPGDKDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
| US-20180362509-A1 | AMINOPYRAZOLE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2018-12-20 | — | — | US | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016204261-A1 | AMINOPYRAZOLE DERIVATIVES | 中外製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | ALDH1A1 1534/4885HPGD 4029/4885KDM4E 1788/4885 |
| US-20180362509-A1 | AMINOPYRAZOLE DERIVATIVES | SRC, GRK2, GRK3 | ALDH1A1 1534/4885HPGD 4029/4885KDM4E 1788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.