Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 4/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.31 |
| ▸ | CDK2 | P24941 | 4/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18331712 | 0.84 | PIK3CD (0.31) | PIK3CD | |
| SCHEMBL22339126 | 0.82 | PIK3CD (0.35) | PIK3CDNAAA | |
| SCHEMBL10252597 | 0.79 | PIK3CD (0.30) | PIK3CD | |
| SCHEMBL12195850 | 0.77 | ALDH1A1 (0.36) | LMNANPC1 | |
| SCHEMBL18109143 | 0.75 | ALDH1A1 (0.36) | NPC1NAAA | |
| SCHEMBL18332195 | 0.74 | PIK3CD (0.33) | PIK3CD | |
| SCHEMBL21572217 | 0.73 | KDM4E (0.33) | PIK3CDNPC1 | |
| SCHEMBL18332412 | 0.73 | DUT (0.32) | PIK3CD | |
| SCHEMBL23009276 | 0.73 | PIK3CD (0.33) | PIK3CD | |
| SCHEMBL22290089 | 0.72 | NAAA (0.41) | NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016204261-A1 | AMINOPYRAZOLE DERIVATIVES | 中外製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |