Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | TP53 | P04637 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Neocryptolepine SCHEMBL29349695 | 1.00 | TERT (0.59) | TERTKDM4ENPC1RAB9AKMT2A | |
| SCHEMBL16692191 | 0.81 | KDM4E (0.64) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9976897 | 0.80 | KDM4E (0.53) | TERTKDM4ENPC1RAB9AKMT2A | |
| SCHEMBL21660657 | 0.79 | RECQL (0.51) | TERTKDM4ERAB9AKMT2AALDH1A1 | |
| SCHEMBL9611813 | 0.78 | KDM4E (0.50) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL16692197 | 0.77 | MEN1 (0.57) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL21660628 | 0.75 | KDM4E (0.41) | TERTKDM4ENPC1RAB9AKMT2A | |
| Cryptolepine SCHEMBL542771 | 0.75 | TERT (1.00) | TERTKDM4EKMT2AALDH1A1MCL1 | |
| SCHEMBL28411392 | 0.75 | ALDH1A1 (0.61) | TERTKDM4ENPC1RAB9AKMT2A | |
| SCHEMBL25636629 | 0.74 | NPC1 (0.59) | TERTKDM4ENPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994018203-A1 | ALKALOID COMPOUNDS EXTRACTED FROM CRYPTOLEPIS SANQUINOLENTA AND USES THEREOF | HEALTHSEARCH, INC. (US) | 1994-08-18 | — | — | WO | claimed |
| CN-113229286-A | Bactericidal composition containing neobynine derivatives and anthraquinone derivatives | 兰州大学 | 2021-08-10 | — | — | CN | disclosed |
| CN-105001220-B | Preparation method of indoloquinoline alkaloid analogues | 渤海大学 | 2017-01-11 | — | — | CN | disclosed |
| CN-105001220-A | Preparation method of indoloquinoline alkaloid analogues | UNIV BOHAI | 2015-10-28 | — | — | CN | disclosed |
| WO-2015147666-A1 | N-GUANYL DERIVATIVES OF 9-AMINO-5.1 1 -DIMETHYL-5H-INDOLO[2,3-B]QUINOLINE HAVING CYTOTOXIC ACTIVITY | INSTYTUT FARMACEUTYCZNY (PL) | 2015-10-01 | — | — | WO | disclosed |
| CN-102924448-B | Alkaloid cryptolepine analogue quindoline acid compound and preparation method | UNIV BOHAI | 2015-02-25 | — | — | CN | disclosed |
| US-8663915-B2 | Methods of controlling tumorigenesis and diagnosing the risk thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2014-03-04 | — | — | US | disclosed |
| CN-102924448-A | Alkaloid cryptolepine analogue quindoline acid compound and preparation method | UNIV BOHAI | 2013-02-13 | — | — | CN | disclosed |
| US-20120269732-A1 | METHODS OF CONTROLLING TUMORIGENESIS AND DIAGNOSING THE RISK THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-10-25 | — | — | US | disclosed |
| EP-2320917-A1 | METHODS OF PREVENTING, ARRESTING OR REVERSING TUMOURIGENESIS AND OF IDENTIFYING COMPOUNDS CAPABLE OF THE SAME | Agency for Science, Technology And Research (SG) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010014043-A1 | METHODS OF PREVENTING, ARRESTING OR REVERSING TUMOURIGENESIS AND OF IDENTIFYING COMPOUNDS CAPABLE OF THE SAME | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-02-04 | — | — | WO | disclosed |
| EP-2146740-A1 | METHODS OF CONTROLLING TUMORIGENESIS AND DIAGNOSING THE RISK THEREOF | Agency for Science, Technology And Research (SG) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008127199-A1 | METHODS OF CONTROLLING TUMORIGENESIS AND DIAGNOSING THE RISK THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2008-10-23 | — | — | WO | disclosed |
| US-20080145346-A1 | Methods And Compounds For Altering The Load Of Hepatitis Virus | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2008-06-19 | — | — | US | disclosed |
| EP-1709178-A1 | METHODS AND COMPOUNDS FOR ALTERING THE LOAD OF HEPATITIS VIRUS | Agency for Science, Technology and Research (SG) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059138-A1 | METHODS AND COMPOUNDS FOR ALTERING THE LOAD OF HEPATITIS VIRUS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2005-06-30 | — | — | WO | disclosed |
| WO-1994018203-A1 | ALKALOID COMPOUNDS EXTRACTED FROM CRYPTOLEPIS SANQUINOLENTA AND USES THEREOF | HEALTHSEARCH, INC. (US) | 1994-08-18 | — | — | WO | disclosed |