Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.73 |
| ▸ | SLC22A2 | O15244 | 5/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 5/20 | 0.73 |
| ▸ | SLC22A3 | O75751 | 5/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 4/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447318 | 0.85 | SLC22A2 (1.00) | PLAUSLC22A2SLC22A1SLC22A3POLB | |
| Hydrochloric Acid SCHEMBL1115167 | 0.83 | SLC22A2 (0.95) | PLAUSLC22A2SLC22A1SLC22A3POLB | |
| Nitric Acid SCHEMBL6033862 | 0.82 | CA12 (0.72) | PLAUSLC22A2SLC22A1SLC22A3POLB | |
| Nitric Acid SCHEMBL2544085 | 0.81 | PLAU (0.73) | PLAUSLC22A2SLC22A1SLC22A3POLB | |
| Nitric Acid SCHEMBL4613845 | 0.81 | PLAU (0.73) | PLAUSLC22A2SLC22A1SLC22A3POLB | |
| Nitric Acid SCHEMBL3860515 | 0.81 | PLAU (0.92) | PLAUPOLBNOS1ADRA2AADRA2B | |
| Phenylguanidine SCHEMBL6129042 | 0.80 | PLAU (0.71) | PLAUSLC22A2SLC22A1SLC22A3POLB | |
| Nitric Acid SCHEMBL3250038 | 0.79 | HTR3E (0.48) | PLAUSLC22A2SLC22A1SLC22A3NOS1 | |
| SCHEMBL240459 | 0.76 | PLAU (1.00) | PLAUPOLBNOS1ADRA2AADRA2B | |
| Nitric Acid SCHEMBL6033181 | 0.75 | PLAU (0.54) | PLAUSLC22A2POLBNOS1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |
| US-6599908-B1 | Potent and selective inhibitors of the protein tyrosine kinases p56lck and p59fyn | CELLTECH R & D LIMITED (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6057329-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-05-02 | — | — | US | disclosed |
| EP-0946523-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028281-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS PROTEIN TYROSINE KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-07-02 | — | — | WO | disclosed |