Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.73 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.73 |
| ▸ | HTR3B | O95264 | 5/20 | 0.73 |
| ▸ | HTR3A | P46098 | 5/20 | 0.73 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.73 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.73 |
| ▸ | SLC22A2 | O15244 | 5/20 | 0.73 |
| ▸ | SLC22A1 | O15245 | 5/20 | 0.73 |
| ▸ | SLC22A3 | O75751 | 5/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 4/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4100900 | 0.85 | HTR3E (1.00) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL28627530 | 0.83 | HTR3E (0.95) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6033862 | 0.82 | CA12 (0.72) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Bicarbonate SCHEMBL27729117 | 0.82 | HTR3E (0.83) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL3860515 | 0.81 | PLAU (0.92) | PLAUPOLBNOS1NOS3NOS2 | |
| Nitric Acid SCHEMBL4613845 | 0.81 | PLAU (0.73) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL1833741 | 0.81 | PLAU (0.73) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Phenylguanidine SCHEMBL6129042 | 0.80 | PLAU (0.71) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL6034257 | 0.80 | ITGB3 (0.60) | PLAUHTR3EHTR3BHTR3AHTR3D | |
| Nitric Acid SCHEMBL2862598 | 0.79 | HTR3E (0.77) | PLAUHTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263901-A1 | Process of Preparation of Proguanil | USV LTD. (IN) | 2011-10-27 | — | — | US | disclosed |
| EP-2150528-A2 | PROCESS FOR PREPARATION OF PROGUANIL HYDROCHLORIDE | USV Limited (IN) | 2010-02-10 | — | — | EP | disclosed |
| WO-2009113092-A2 | PROCESS FOR PREPARATION OF PROGUANIL HYDROCHLORIDE | USV LIMITED (IN) | 2009-09-17 | — | — | WO | disclosed |
| US-4587337-A | Process for the preparation of 2-amino-s-triazines | SKW TROSTBERG AKTIENGESELLSCHAFT (DE) | 1986-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263901-A1 | Process of Preparation of Proguanil | GCG, PREP, G6PD | PLAU 365/4885HTR3E 1857/4885HTR3B 983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.