Sugi Predict

Sugi Predict / Compounds / SCHEMBL18338189

SCHEMBL18338189

SCHEMBL18338189

CCNc1ccc(CO[Si](C)(C)C(C)(C)C)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.35
▸ ADRA2A P08913 4/20 0.34
▸ KMT2A Q03164 3/20 0.34
▸ ADRA2B P18089 2/20 0.34
▸ ADRA2C P18825 2/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ POLB P06746 2/20 0.34
▸ GAA P10253 2/20 0.34
▸ HPGD P15428 2/20 0.34
▸ ALOX15 P16050 2/20 0.34
▸ MAPK1 P28482 2/20 0.34
▸ CASP1 P29466 2/20 0.34
▸ BLM P54132 2/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.34
▸ APAF1 O14727 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ ALOX12 P18054 1/20 0.34
▸ LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17361958 0.83 APP (0.44) KMT2AMEN1ALDH1A1HPGDALOX15
SCHEMBL18338150 0.81 THRA (0.42) MAPTBACE1THRB
SCHEMBL15062755 0.81 LPL (0.37) MAPTADRA2AALDH1A1POLBGAA
SCHEMBL15489965 0.80 TDP1 (0.37) KMT2AALDH1A1L3MBTL1BACE1HSP90AA1
SCHEMBL906834 0.77 IDO1 (0.48) KMT2AMEN1HPGDBLMHSD17B10
SCHEMBL12855670 0.77 AGXT (0.52) CA1CA2
SCHEMBL11079024 0.76 TSHR (0.49) MAPTKMT2AMEN1ALDH1A1L3MBTL1
SCHEMBL19306519 0.76 KLK7 (0.41) KMT2AMEN1HPGDHSD17B10L3MBTL1
SCHEMBL31138172 0.76 BACE1 (0.36) BACE1
SCHEMBL17030654 0.75 IDO1 (0.50) MAPTKMT2AMEN1L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107922428-B Thienopyrrole compounds and their use as inhibitors of oplophorus-derived luciferase 普洛麦格公司 2021-02-05 — — CN disclosed
EP-3313846-B1 THIENOPYRROLE COMPOUNDS AND USES THEREOF AS INHIBITORS OF OPLOPHORUS-DERIVED LUCIFERASES PROMEGA CORP (US) 2020-05-06 — — EP disclosed
US-20200063110-A1 THIENOPYRROLE COMPOUNDS AND USES THEREOF PROMEGA CORPORATION 2020-02-27 — — US disclosed
EP-3313846-A1 THIENOPYRROLE COMPOUNDS AND USES THEREOF AS INHIBITORS OF OPLOPHORUS-DERIVED LUCIFERASES Promega Corporation (US) 2018-05-02 — — EP disclosed
WO-2016210294-A1 THIENOPYRROLE COMPOUNDS AND USES THEREOF AS INHIBITORS OF OPLOPHORUS-DERIVED LUCIFERASES PROMEGA CORPORATION (US) 2016-12-29 — — WO disclosed
US-20160376568-A1 THIENOPYRROLE COMPOUNDS AND USES THEREOF JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2016-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160376568-A1 THIENOPYRROLE COMPOUNDS AND USES THEREOF THOP1, TYMP, CREBBP MAPT 2973/4885ADRA2A 1492/4885KMT2A 2923/4885
US-20200063110-A1 THIENOPYRROLE COMPOUNDS AND USES THEREOF THOP1, TYMP, CREBBP MAPT 2973/4885ADRA2A 1492/4885KMT2A 2923/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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