Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.49 |
| ▸ | BTK | Q06187 | 11/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18341474 | 0.83 | IRAK4 (0.65) | IRAK4 | |
| SCHEMBL18341558 | 0.81 | HTR4 (0.44) | IRAK4 | |
| SCHEMBL18341542 | 0.71 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL30508193 | 0.68 | BMPR1B (0.44) | IRAK4BTKCNR2 | |
| SCHEMBL17796380 | 0.67 | EGLN1 (0.49) | IRAK4CNR2 | |
| SCHEMBL17796768 | 0.67 | EGLN1 (0.49) | IRAK4CNR2 | |
| SCHEMBL26598605 | 0.67 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL31436622 | 0.67 | IRAK4 (0.61) | IRAK4 | |
| SCHEMBL30606157 | 0.66 | HPGD (0.58) | IRAK4CNR2 | |
| SCHEMBL26100982 | 0.66 | HPGD (0.58) | IRAK4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475270-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2016210036-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-12-29 | — | — | WO | disclosed |