Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18656761 | 0.72 | MEN1 (0.41) | LMNASMN1; SMN2SRCLRRK2ADORA2A | |
| SCHEMBL29407793 | 0.71 | LRRK2 (0.54) | SRCLRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL22658714 | 0.71 | LRRK2 (0.54) | SRCLRRK2ADORA3ADORA2AADORA1 | |
| SCHEMBL14193669 | 0.70 | SRC (0.50) | LMNASMN1; SMN2ALDH1A1PTGS2SRC | |
| SCHEMBL18341978 | 0.69 | MEN1 (0.35) | SRCADORA3ADORA2AADORA1 | |
| SCHEMBL18656780 | 0.69 | MEN1 (0.35) | SRCADORA2AADORA1 | |
| SCHEMBL18656782 | 0.69 | MEN1 (0.33) | SRCLRRK2 | |
| SCHEMBL18342030 | 0.69 | HRH4 (0.43) | LMNASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4066247 | 0.69 | ADORA3 (0.57) | LMNASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL16815522 | 0.66 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137497-B | Bicyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2021-06-15 | — | — | CN | disclosed |
| EP-3313817-B1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2020-09-16 | — | — | EP | disclosed |
| US-10618909-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-04-14 | — | — | US | disclosed |
| US-20190248805-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-08-15 | — | — | US | disclosed |
| US-10323041-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-06-18 | — | — | US | disclosed |
| US-20180258098-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-09-13 | — | — | US | disclosed |
| EP-3313817-A1 | NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016207217-A1 | NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2016-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10618909-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | BAX, CASP3, CASP4 | LMNA 53/4885SMN1; SMN2 1448/4885ALDH1A1 2683/4885 |
| US-20180258098-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, CASP3, CASP4 | LMNA 53/4885SMN1; SMN2 1501/4885ALDH1A1 2755/4885 |
| US-20190248805-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, CASP3, CASP4 | LMNA 53/4885SMN1; SMN2 1448/4885ALDH1A1 2683/4885 |
| US-10323041-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | BAX, CASP3, CASP4 | LMNA 53/4885SMN1; SMN2 1448/4885ALDH1A1 2683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.