Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14883268 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL14875737 | 0.83 | XDH (0.55) | ALDH1A1KDM4ESMN1; SMN2HPGDTYMS | |
| SCHEMBL18351088 | 0.81 | MAPK1 (0.55) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL18351100 | 0.79 | ADORA3 (0.61) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL18351095 | 0.77 | MAPK1 (0.58) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL18351094 | 0.77 | MAPK1 (0.58) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL18351089 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL18351096 | 0.75 | MAPK1 (0.55) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT | |
| SCHEMBL14875833 | 0.75 | DHFR (0.56) | ALDH1A1KDM4ESMN1; SMN2HPGDRXFP1 | |
| SCHEMBL18351099 | 0.75 | MAPK1 (0.55) | ALDH1A1KDM4ESMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376286-A1 | Pyrimidin-4-one derivatives and their use in the tratement, amelioration or prevention of a viral disease | F. HOFFMAN-LA ROCHE LTD | 2016-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376286-A1 | Pyrimidin-4-one derivatives and their use in the tratement, amelioration or prevention of a viral disease | TTR, TYMP, TPMT | ALDH1A1 464/4885KDM4E 3351/4885SMN1; SMN2 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.