Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18354405 | 0.95 | DHODH (0.38) | DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL18354699 | 0.94 | DHODH (0.37) | DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL18354199 | 0.94 | DHODH (0.38) | DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL17482156 | 0.93 | DHODH (0.37) | DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL18354050 | 0.93 | DHODH (0.37) | DHODHTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL18354718 | 0.92 | TAS1R3 (0.39) | DHODHTAS1R3TAS1R1TAS1R2MRGPRX4 | |
| SCHEMBL18354398 | 0.91 | MLYCD (0.39) | DHODH | |
| SCHEMBL18360165 | 0.91 | DHODH (0.38) | DHODHTAS1R3TAS1R1TAS1R2MRGPRX4 | |
| SCHEMBL18354645 | 0.91 | HDAC8 (0.34) | DHODHSCN8ASCN10A | |
| SCHEMBL18354196 | 0.91 | MAPT (0.37) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210051955-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2021-02-25 | — | — | US | disclosed |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-22 | — | — | US | disclosed |
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-22 | — | — | US | disclosed |
| US-9839216-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-12 | — | — | US | disclosed |
| US-9839216-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2017-12-12 | — | — | US | disclosed |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-05 | — | — | US | disclosed |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180077930-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | DHODH 3024/4885TAS1R3 381/4885TAS1R1 817/4885 |
| US-20210051955-A1 | INSECTICIDAL COMPOUNDS | ACHE, CYP4X1, ITPR3 | DHODH 3024/4885TAS1R3 381/4885TAS1R1 817/4885 |
| US-20170000120-A1 | INSECTICIDAL COMPOUNDS | ACHE, HDAC6, TUBA3C | DHODH 3226/4885TAS1R3 455/4885TAS1R1 1016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.