Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084402 | 0.78 | BRD4 (0.44) | — | |
| SCHEMBL15065782 | 0.78 | BRD4 (0.44) | — | |
| SCHEMBL15065780 | 0.78 | BRD4 (0.44) | — | |
| SCHEMBL15065779 | 0.78 | BRD4 (0.44) | — | |
| SCHEMBL24989398 | 0.70 | GPR119 (0.47) | USP30NR1H2RXRANR1H3RORC | |
| SCHEMBL18360704 | 0.69 | USP30 (0.39) | USP30NR1H2RXRANR1H3RORC | |
| SCHEMBL807208 | 0.67 | RORC (0.52) | USP30TACR1NR1H2RXRANR1H3 | |
| SCHEMBL23951812 | 0.67 | USP30 (0.44) | USP30TACR1ADAM17RORCPDE4B | |
| SCHEMBL19203135 | 0.66 | PDE4B (0.59) | USP30TACR1RORCPDE4B | |
| SCHEMBL2242155 | 0.64 | PDE4B (0.51) | USP30TACR1MAPK1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |