Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241389 | 1.00 | PDE4B (0.51) | PDE4BUSP30TACR1YAP1MAPT | |
| SCHEMBL2240609 | 0.90 | PDE4B (0.51) | PDE4BUSP30TACR1YAP1MAPT | |
| SCHEMBL2816531 | 0.88 | EPHX1 (0.46) | PDE4BTACR1HSD11B1ALDH1A1 | |
| SCHEMBL2240103 | 0.88 | EPHX1 (0.46) | PDE4BTACR1HSD11B1ALDH1A1 | |
| SCHEMBL19893582 | 0.84 | PDE4B (0.52) | PDE4BUSP30TACR1HSD11B1L3MBTL1 | |
| SCHEMBL19893581 | 0.84 | PDE4B (0.52) | PDE4BUSP30TACR1HSD11B1L3MBTL1 | |
| SCHEMBL19893583 | 0.84 | PDE4B (0.52) | PDE4BUSP30TACR1HSD11B1L3MBTL1 | |
| SCHEMBL6356119 | 0.84 | HSD11B1 (0.49) | PDE4BUSP30MAPTMAPK1NPSR1 | |
| SCHEMBL30889444 | 0.83 | PDE4B (0.58) | PDE4BTACR1MAPTL3MBTL1KMT2A | |
| SCHEMBL29492127 | 0.83 | HSD11B1 (0.50) | PDE4BUSP30MAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110190278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO. | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVE | REN, AGTR1, AGTR2 | PDE4B 1236/4885USP30 3836/4885TACR1 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.