Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pamidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 19/20 | 0.95 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.95 |
| ▸ | LMNA | P02545 | 1/20 | 0.95 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.95 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.95 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamidronic Acid SCHEMBL570527 | 1.00 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL5718109 | 0.97 | FDPS (0.90) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL18361 | 0.97 | FDPS (1.00) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8642786 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8850008 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL31388517 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL7755905 | 0.88 | FDPS (0.82) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL140618 | 0.85 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL140619 | 0.85 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL1115700 | 0.85 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421921-B1 | Double coated granules | CIBA GEIGY AG (CH) | 1994-04-27 | — | — | EP | claimed |
| US-5096717-A | Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate; controlle d release; oral administration; hydrophilic, elastic coating a nd gastric juice-resistant, intestinal juice-soluble coating; granulation and coating | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | claimed |
| EP-0177443-B1 | CRYSTAL MODIFICATION OF DISODIUM-3-AMINO-1-HYDROXY-PROPANE-1,1-DIPHOSPHONATE | CIBA-GEIGY AG (CH) | 1989-10-18 | — | — | EP | claimed |
| US-4711880-A | FOR CALCIUM AND PHOSPHATE METABOLISM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1987-12-08 | — | — | US | claimed |
| US-4639338-A | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate | CIBA-GEIGY CORPORATION (US) | 1987-01-27 | — | — | US | claimed |
| JP-3099016-A | — | — | None | — | — | JP | disclosed |
| EP-2155769-B1 | TISSUE DEGENERATION PROTECTION | UNIV LEUVEN KATH (BE) | 2012-06-27 | — | — | EP | disclosed |
| EP-2398472-A2 | METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS WITH A POLYAMINE (E.G. SPERMINE, SPERMIDINE) | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010081204-A2 | ACTIVATORS OF THE AUTOPHAGIC PATHWAY | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081862-A2 | METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2010-07-22 | — | — | WO | disclosed |
| EP-1414486-B1 | USE OF GLP-2 IN COMBINATION WITH ANOTHER THERAPEUTIC AGENT IN BONE-RELATED DISORDERS | SANOS BIOSCIENCE AS (DK) | 2010-05-05 | — | — | EP | disclosed |
| EP-2155769-A2 | TISSUE DEGENERATION PROTECTION | Katholieke Universiteit Leuven (BE) | 2010-02-24 | — | — | EP | disclosed |
| JP-H0399016-A | DOUBLE COATED GRANULE | CIBA GEIGY AG | 1991-04-24 | — | — | JP | disclosed |
| US-4711880-A | FOR CALCIUM AND PHOSPHATE METABOLISM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1987-12-08 | — | — | US | disclosed |
| US-4711880-A | FOR CALCIUM AND PHOSPHATE METABOLISM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1987-12-08 | — | — | US | disclosed |
| US-4639338-A | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate | CIBA-GEIGY CORPORATION (US) | 1987-01-27 | — | — | US | disclosed |
| US-4639338-A | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate | CIBA-GEIGY CORPORATION (US) | 1987-01-27 | — | — | US | disclosed |
| US-4578376-A | 6-AMINO-1-HYDROXYHEXANE-1,1-DIPHOSPHONIC ACID; PAGET'S DOSEASE | ISTITUTO GENTILI S.P.A. (IT) | 1986-03-25 | — | — | US | disclosed |
| US-4104366-A | Compositions for preparation of aqueous solutions of low valence 99 technitium salts | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1978-08-01 | — | — | US | disclosed |
| US-4086334-A | A CALCITONIN AND AN ADJUVANT CONTAINING CARBOXY AND/OR PHOSPHONO GROUPS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DT) | 1978-04-25 | — | — | US | disclosed |