Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pamidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 19/20 | 0.95 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.95 |
| ▸ | LMNA | P02545 | 1/20 | 0.95 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.95 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.95 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamidronic Acid SCHEMBL5718109 | 0.97 | FDPS (0.90) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL18361 | 0.97 | FDPS (1.00) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL2787529 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8642786 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL570527 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL31388517 | 0.95 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL7755905 | 0.88 | FDPS (0.82) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL303564 | 0.85 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL167772 | 0.85 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL2641229 | 0.84 | FDPS (0.68) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022214707-A1 | CELLULAR REPORTER AND METHODS OF USING THE SAME | GADETA B.V. (NL) | 2022-10-13 | — | — | WO | disclosed |
| EP-0617624-B1 | TREATMENT OF PERIODONTAL DISEASE WITH ALENDRONATE | MERCK & CO INC (US) | 1997-03-26 | — | — | EP | disclosed |
| EP-0617624-A1 | TREATMENT OF PERIODONTAL DISEASE WITH ALENDRONATE. | MERCK & CO INC (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5270365-A | Prevention and treatment of periodontal disease with alendronate | MERCK & CO., INC. (US) | 1993-12-14 | — | — | US | disclosed |
| WO-1993011774-A1 | TREATMENT OF PERIODONTAL DISEASE WITH ALENDRONATE | MERCK & CO., INC. (US) | 1993-06-24 | — | — | WO | disclosed |