Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pamidronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 19/20 | 0.90 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.90 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.90 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.90 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamidronic Acid SCHEMBL570527 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8850008 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL2787529 | 0.97 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL18361 | 0.95 | FDPS (1.00) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL31388517 | 0.92 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL8642786 | 0.92 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5973522 | 0.86 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL7831398 | 0.86 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5973509 | 0.86 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Pamidronic Acid SCHEMBL7755905 | 0.86 | FDPS (0.82) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107974-B1 | NOVEL HYDRATE FORMS OF ALENDRONATE SODIUM, PROCESSES FOR MANUFACTURE THEREOF, AND PHARMACEUTICAL COMPOSITIONS THEREOF | TEVA PHARMA (IL) | 2006-08-02 | — | — | EP | disclosed |
| EP-0800397-B1 | BONE MASS ANABOLIC COMPOSITION COMPRISING OLPADRONATE | GADOR SA (AR) | 2006-04-05 | — | — | EP | disclosed |
| EP-0891979-B1 | A crystalline form of monohydrate monosodium salt of the N,N-Dimethyl-3-amino-1-Hydroxypropan-1,1-Disphosphonic acid and the procedure for its preparation | GADOR SA (AR) | 2004-10-20 | — | — | EP | disclosed |
| US-5885973-A | Bone mass anabolic composition comprising olpadronate | GADOR, S.A. (AR) | 1999-03-23 | — | — | US | disclosed |
| EP-0891979-A1 | A crystalline form of monohydrate monosodium salt of the N,N-Dimethyl-3-amino-1-Hydroxypropan-1,1-Disphosphonic acid and the procedure for its preparation | GADOR S.A. (AR) | 1999-01-20 | — | — | EP | disclosed |
| US-4711880-A | FOR CALCIUM AND PHOSPHATE METABOLISM DISORDERS | CIBA-GEIGY CORPORATION (US) | 1987-12-08 | — | — | US | disclosed |
| US-4639338-A | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate | CIBA-GEIGY CORPORATION (US) | 1987-01-27 | — | — | US | disclosed |