Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18350252 | 0.88 | CHRNA7 (0.40) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL18361797 | 0.83 | FAAH (0.41) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL20681941 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL16700446 | 0.80 | TEAD2 (0.41) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL18350265 | 0.79 | MEN1 (0.40) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL16700430 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1POLBTDP1LMNA | |
| SCHEMBL2173892 | 0.76 | TSHR (0.57) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL5022767 | 0.74 | TSHR (0.58) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL16730921 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AALDH1A1POLB | |
| SCHEMBL18003909 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189843-B2 | Fused pyrazole derivative having autotaxin inhibitory activity | THE UNIVERSITY OF TOKYO (JP) | 2019-01-29 | — | — | US | disclosed |
| EP-3112369-A1 | FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY | The University of Tokyo (JP) | 2017-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189843-B2 | Fused pyrazole derivative having autotaxin inhibitory activity | ENPP2, PRTN3, TPX2 | SMN1; SMN2 4197/4885NPC1 3328/4885RAB9A 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.