Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 4/20 | 0.32 |
| ▸ | BCL2 | P10415 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | BAD | Q92934 | 1/20 | 0.30 |
| ▸ | RHEB | Q15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361808 | 0.83 | LOXL2 (0.45) | LOXL2MCL1PPARAPPARGMAPT | |
| SCHEMBL20337854 | 0.82 | LOXL2 (0.39) | LOXL2MCL1PPARAPPARGLMNA | |
| SCHEMBL18361832 | 0.81 | LOXL2 (0.44) | LOXL2MAPTKDRRHEB | |
| SCHEMBL18362071 | 0.79 | LOXL2 (0.52) | LOXL2MCL1PPARAPPARGPPARD | |
| SCHEMBL18362172 | 0.79 | LOXL2 (0.42) | LOXL2MCL1BCL2MAPTKDR | |
| SCHEMBL18361805 | 0.78 | PPARG (0.44) | MCL1PPARAPPARGBCL2PPARD | |
| SCHEMBL20337881 | 0.73 | ALDH1A1 (0.49) | LOXL2PPARAPPARGLMNA | |
| SCHEMBL18362016 | 0.72 | LOXL2 (0.73) | LOXL2LMNATSHR | |
| SCHEMBL18361811 | 0.71 | HTR2C (0.53) | MCL1PPARABAD | |
| SCHEMBL18361841 | 0.69 | LOXL2 (0.68) | LOXL2KDRRHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017003862-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-01-05 | — | — | WO | disclosed |