Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CYP24A1 | Q07973 | 4/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | BAD | Q92934 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361805 | 0.80 | PPARG (0.44) | MCL1BADPPARA | |
| SCHEMBL4651322 | 0.77 | HTR2C (0.65) | HTR2CCDK4CCND1CNR1CNR2 | |
| SCHEMBL20337987 | 0.74 | HTR2C (0.53) | HTR2CNR3C1PGRNR3C2HTR6 | |
| SCHEMBL4652431 | 0.74 | HTR2C (0.69) | HTR2CCDK4CCND1HTR6CNR1 | |
| SCHEMBL4612283 | 0.73 | HTR2C (0.83) | HTR2CHTR6HTR2A | |
| SCHEMBL3245076 | 0.72 | HTR2C (0.66) | HTR2CCDK4CCND1HTR6CNR2 | |
| SCHEMBL18361806 | 0.71 | LOXL2 (0.39) | MCL1BADPPARA | |
| SCHEMBL27587633 | 0.71 | HTR2C (0.56) | HTR2CHTR6MCL1S1PR1BAD | |
| SCHEMBL4329033 | 0.71 | HTR2C (0.73) | HTR2CHTR6HTR2A | |
| SCHEMBL4323537 | 0.70 | HTR2C (0.63) | HTR2CNR3C1PGRNR3C2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017003862-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2017-01-05 | — | — | WO | disclosed |