Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18364903 | 0.96 | ATM (0.44) | ATMLMNASMN1; SMN2TXNRD1HCAR2 | |
| SCHEMBL18364421 | 0.90 | ATM (0.44) | ATMLMNASMN1; SMN2TXNRD1HCAR2 | |
| SCHEMBL18364427 | 0.87 | TXNRD1 (0.38) | ATMLMNASMN1; SMN2TXNRD1HCAR2 | |
| SCHEMBL18364446 | 0.84 | ATM (0.44) | ATMLMNASMN1; SMN2HCAR2KEAP1 | |
| SCHEMBL18355259 | 0.80 | ATM (0.47) | ATMLMNASMN1; SMN2HCAR2KEAP1 | |
| SCHEMBL18354877 | 0.80 | ATM (0.41) | ATMLMNASMN1; SMN2TXNRD1HCAR2 | |
| SCHEMBL18364410 | 0.80 | ATM (0.41) | ATMLMNASMN1; SMN2HCAR2KEAP1 | |
| SCHEMBL18364893 | 0.79 | ATM (0.48) | ATMLMNASMN1; SMN2HCAR2KEAP1 | |
| SCHEMBL17695736 | 0.78 | LMNA (0.55) | ATMLMNASMN1; SMN2HCAR2KEAP1 | |
| SCHEMBL8016512 | 0.78 | LMNA (0.55) | ATMLMNASMN1; SMN2HCAR2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008835-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-01-12 | — | — | US | disclosed |
| US-20170008835-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | Nguyen, Mark Quang (US) | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008835-A1 | FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | FH, FPGS, APC | ATM 4406/4885LMNA 4358/4885SMN1; SMN2 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.