SCHEMBL18364671

SCHEMBL18364671

COc1ccc(/C=C/C(=O)O[C@@H]2CCCC[C@H]2OC(=O)/C=C/c2ccc(OC)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.61
TRPM8 Q7Z2W7 2/20 0.60
RAB9A P51151 2/20 0.60
F3 P13726 2/20 0.58
THRB P10828 1/20 0.57
ATM Q13315 1/20 0.57
GSK3B P49841 2/20 0.55
MEN1 O00255 1/20 0.55
MAPT P10636 1/20 0.55
KMT2A Q03164 1/20 0.55
HDAC3 O15379 2/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC2 Q92769 2/20 0.54
HDAC8 Q9BY41 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
BACE1 P56817 1/20 0.51
LMNA P02545 2/20 0.51
TDP1 Q9NUW8 1/20 0.51
ALDH1A1 P00352 2/20 0.50
NPC1 O15118 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20306019 0.94 MAOA (0.58) HTTTRPM8RAB9AF3THRB
SCHEMBL13899764 0.87 F3 (0.57) HTTTRPM8RAB9AF3THRB
SCHEMBL600597 0.87 HTT (0.70) HTTTRPM8RAB9AF3THRB
SCHEMBL154420 0.87 HTT (0.70) HTTTRPM8RAB9AF3THRB
SCHEMBL12608600 0.84 HTT (0.67) HTTTRPM8RAB9AF3THRB
SCHEMBL701486 0.83 USP2 (0.52) HTTMEN1KMT2AHDAC2LMNA
SCHEMBL699090 0.83 CYP2C19 (0.51) TRPM8RAB9AF3MEN1MAPT
SCHEMBL12621076 0.81 BCHE (0.56) HTTTRPM8RAB9AF3THRB
SCHEMBL14984252 0.81 BCHE (0.56) HTTTRPM8RAB9AF3THRB
SCHEMBL26012717 0.81 BCHE (0.56) HTTTRPM8RAB9AF3THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10007042-B2 Composition, light reflecting film, luminance-improving film, backlight unit, and liquid crystal display device FUJIFILM CORPORATION (JP) 2018-06-26 US disclosed
US-10007042-B2 Composition, light reflecting film, luminance-improving film, backlight unit, and liquid crystal display device FUJIFILM CORPORATION (JP) 2018-06-26 US disclosed
US-20170010398-A1 COMPOSITION, LIGHT REFLECTING FILM, LUMINANCE-IMPROVING FILM, BACKLIGHT UNIT, AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2017-01-12 US disclosed
US-20170010398-A1 COMPOSITION, LIGHT REFLECTING FILM, LUMINANCE-IMPROVING FILM, BACKLIGHT UNIT, AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2017-01-12 US disclosed