Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.48 |
| ▸ | CDK2 | P24941 | 9/20 | 0.48 |
| ▸ | CDK9 | P50750 | 9/20 | 0.48 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.48 |
| ▸ | CDK7 | P50613 | 4/20 | 0.48 |
| ▸ | CCNH | P51946 | 4/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28690545 | 0.93 | EGFR (0.54) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376244 | 0.91 | JAK2 (0.52) | EGFRJAK2JAK3JAK1BRD4 | |
| SCHEMBL18376831 | 0.90 | EGFR (0.56) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376785 | 0.89 | TBK1 (0.48) | EGFRCDK1SYKJAK2JAK3 | |
| SCHEMBL18376839 | 0.88 | EGFR (0.53) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376835 | 0.87 | EGFR (0.58) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376829 | 0.85 | EGFR (0.60) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376833 | 0.85 | EGFR (0.56) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376832 | 0.84 | JAK2 (0.58) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL18376747 | 0.84 | EGFR (0.59) | EGFRCCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |