Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090177 | 0.84 | HRH3 (0.56) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 | |
| SCHEMBL662136 | 0.83 | HRH3 (0.46) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 | |
| SCHEMBL30398570 | 0.81 | HRH3 (0.55) | HRH3CYP1A2CYP2D6L3MBTL1NPC1 | |
| SCHEMBL487617 | 0.81 | HRH3 (0.55) | HRH3CYP1A2CYP2D6L3MBTL1NPC1 | |
| SCHEMBL2619347 | 0.80 | NFKB1 (0.54) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 | |
| SCHEMBL16935090 | 0.80 | TAAR1 (0.54) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 | |
| SCHEMBL18397399 | 0.79 | PIK3CD (0.40) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 | |
| SCHEMBL31190152 | 0.78 | RAB9A (0.51) | HRH3CYP1A2TDP1L3MBTL1NFKB1 | |
| Ammonia Solution, Strong SCHEMBL7978427 | 0.78 | NFKB1 (0.53) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 | |
| SCHEMBL20415539 | 0.77 | HRH3 (0.41) | HRH3CYP1A2CYP2D6TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325471-A1 | COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS | Genzyme Corporation (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017015267-A1 | COLONY STIMULATING FACTOR-1 RECEPTOR (CSF-1R) INHIBITORS | GENZYME CORPORATION (US) | 2017-01-26 | — | — | WO | disclosed |