Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398609 | 0.84 | TLR7 (0.32) | LMNATLR7ABCB11CDK1 | |
| SCHEMBL18398296 | 0.83 | JAK2 (0.37) | LMNATLR7IKBKBHRH4ALOX15 | |
| SCHEMBL18409422 | 0.77 | CDK1 (0.42) | TLR7CDK1SMN1; SMN2CCNE1CDK2 | |
| SCHEMBL18398421 | 0.77 | JAK2 (0.35) | LMNAIKBKBABCB11CDK1 | |
| SCHEMBL18398339 | 0.75 | HRH4 (0.35) | LMNATLR7HRH4CYP1A2CYP3A4 | |
| SCHEMBL18398366 | 0.75 | LMNA (0.36) | LMNATLR7IKBKBKCNH2 | |
| SCHEMBL18409182 | 0.70 | CDK1 (0.42) | IKBKBCDK1CCNE1CDK2 | |
| SCHEMBL18398295 | 0.69 | MAP2K2 (0.40) | LMNAABCB11KCNH2PKMP2RX7 | |
| SCHEMBL18398495 | 0.69 | MAPT (0.43) | LMNAALOX15HSD17B10GAACYP1A2 | |
| SCHEMBL18398397 | 0.69 | JAK2 (0.49) | LMNAABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |