Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.59 |
| ▸ | BTK | Q06187 | 5/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.52 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29728069 | 1.00 | SYK (0.59) | SYKBTKPDGFRBPDGFRAPIK3CA | |
| SCHEMBL30837522 | 0.90 | NOS1 (0.52) | SYKBTKPDGFRBPDGFRAKDM4E | |
| SCHEMBL5412781 | 0.89 | PLK4 (0.56) | SYKBTKPDGFRBPDGFRAPIK3CA | |
| SCHEMBL30385421 | 0.87 | NOS1 (0.49) | SYKBTKPDGFRBPDGFRAKDM4E | |
| SCHEMBL29039315 | 0.87 | NOS1 (0.49) | SYKBTKPDGFRBPDGFRAKDM4E | |
| SCHEMBL30469212 | 0.85 | TERT (0.53) | SYKBTKPDGFRBPDGFRAKDM4E | |
| SCHEMBL29539832 | 0.84 | PDGFRB (0.55) | SYKBTKPDGFRBPDGFRAKDM4E | |
| SCHEMBL2799745 | 0.84 | PDGFRB (0.55) | SYKBTKPDGFRBPDGFRAKDM4E | |
| SCHEMBL25934033 | 0.83 | LGMN (0.49) | SYKBTKPDGFRBPDGFRAPIK3CA | |
| SCHEMBL5095062 | 0.83 | FGFR1 (0.56) | BTKPDGFRBPDGFRAJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174292-B | Substituted 2-morpholinopyridine derivatives as ATR kinase inhibitors | 修复治疗公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-114174292-A | Substituted 2-morpholinopyridine derivatives as ATR kinase inhibitors | 修复治疗公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-113454080-A | Compounds, pharmaceutical compositions and methods of making compounds and methods of use thereof | 修复治疗公司 | 2021-09-28 | — | — | CN | disclosed |
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |