Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 5/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30837522 | 0.80 | NOS1 (0.52) | SYKMETAP2KDM4EMEN1MAPT | |
| SCHEMBL9983829 | 0.78 | AR (0.48) | ABL1ARCDK1CDK2SLC40A1 | |
| SCHEMBL29039315 | 0.77 | NOS1 (0.49) | SYKMETAP2KDM4EMEN1MAPT | |
| SCHEMBL30385421 | 0.77 | NOS1 (0.49) | SYKMETAP2KDM4EMEN1MAPT | |
| SCHEMBL3190345 | 0.77 | MAPT (0.49) | ABL1SYKMETAP2SLC6A3KDM4E | |
| SCHEMBL5094880 | 0.76 | HTR6 (0.45) | SYKKDM4EMEN1MAPTKMT2A | |
| SCHEMBL30469212 | 0.76 | TERT (0.53) | SYKMETAP2KDM4EMEN1MAPT | |
| SCHEMBL18399012 | 0.75 | SYK (0.59) | SYKMETAP2KDM4EMEN1MAPT | |
| SCHEMBL29539832 | 0.75 | PDGFRB (0.55) | SYKMETAP2KDM4EMEN1MAPT | |
| SCHEMBL29728069 | 0.75 | SYK (0.59) | SYKMETAP2KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |